hello
My name is Iraj Eshghi, welcome to my personal website. I’m a physicist interested in the organizing principles of life and how they go awry. I am currently working as a Postdoctoral Researcher at the New York Genome Center primarily in the Imieliski lab, where I research cancer genomes, their structure, dynamics, and evolution.
Specifically, I study complex structural variants, large changes in genomic ordering, topology, and copy number which occur in many cancers. These are hard to detect and characterize using current methods, but using principled approaches and physical intuition we can make inferences where previously thought impossible. I’m also interested in understanding the ways in which these structures physically interact with themselves and their environment and how this affects cancer development.
My background is in the statistical mechanics of chromatin and any/all soft active matter systems. I’m always curious to learn about any adjacent topics in physics or biology. Don’t hesitate to reach out to discuss new problems and ideas!
email: ieshghi at nygenome dot org
selected publications
4 Aug 2023
Model chromatin flows: numerical analysis of linear and nonlinear hydrodynamics inside a sphere
We solve our previously published active polymer field theory in a confined geometry analytically and numerically, into the nonlinear regime
28 Jul 2023
Activity-driven phase transition causes coherent flows of chromatin
Using a field-theoretic description of active chromatin hydrodynamics, we find a phase transition that explains chromatin’s observed correlated motion
20 Sep 2022
Symmetry-Based Classification of Forces Driving Chromatin Dynamics
Using conservation of momentum to constrain theories of active polymer dynamics
4 Jun 2021
Interphase Chromatin Undergoes a Local Sol-Gel Transition Upon Cell Differentiation
Inferring phase changes in the nucleus from high-resolution microscopy