Iraj Eshghi's Research

hello

My name is Iraj Eshghi, welcome to my personal website. I’m a physicist interested in the organizing principles of life and how they go awry. I am currently working as a Postdoctoral Researcher at the New York Genome Center primarily in the Imieliski lab, where I research cancer genomes, their structure, dynamics, and evolution.

Specifically, I study complex structural variants, large changes in genomic ordering, topology, and copy number which occur in many cancers. These are hard to detect and characterize using current methods, but using principled approaches and physical intuition we can make inferences where previously thought impossible. I’m also interested in understanding the ways in which these structures physically interact with themselves and their environment and how this affects cancer development.

My background is in the statistical mechanics of chromatin and any/all soft active matter systems. I’m always curious to learn about any adjacent topics in physics or biology. Don’t hesitate to reach out to discuss new problems and ideas!

email: ieshghi at nygenome dot org

Google Scholar, Orcid, Github

selected publications

4 Aug 2023

Model chromatin flows: numerical analysis of linear and nonlinear hydrodynamics inside a sphere

We solve our previously published active polymer field theory in a confined geometry analytically and numerically, into the nonlinear regime

28 Jul 2023

Activity-driven phase transition causes coherent flows of chromatin

Using a field-theoretic description of active chromatin hydrodynamics, we find a phase transition that explains chromatin’s observed correlated motion

20 Sep 2022

Symmetry-Based Classification of Forces Driving Chromatin Dynamics

Using conservation of momentum to constrain theories of active polymer dynamics

4 Jun 2021

Interphase Chromatin Undergoes a Local Sol-Gel Transition Upon Cell Differentiation

Inferring phase changes in the nucleus from high-resolution microscopy